MEET THE FACULTY CANDIDATES - PDF
Schmidt Lab Alum Starts Faculty Position .. Postdoc Becky Wachs accepts faculty position .. October , – Great BMES meeting in Tampa, Florida!. BMES Annual Meeting The "Meet-the-Faculty Candidate" poster session provides 1University of South Florida, Tampa, FL. the BMES officers to invite an expert in AllTech company to give a seminar to award to BMES meeting, Department of Biomedical Engineering, University of . using functional MRI”, BMES Annual Scientific Meeting, Tampa, FL,
I demonstrated polarization and osteogenesis inducing potential of pro-inflammatory macrophages and currently validating their in-vivo potential. Overall, the aforementioned research projects embody my long-term goals and future plans in basic and translational research for developing biomaterials-assisted and cell-based therapies for various diseases and disorders.
BTech Bachelor of Technology in Biotechnology, 1st class with distinction. Rumble University Graduate Fellow: Collagen Type II enhances chondrogenic differentiation in agarose-based modular microtissues. Macrophages mediated degradation and release of BMP2 from gelation microspheres for bone regeneration. My group is exploring soft tissue behaviour, in particular that of the lungs, with the aim of characterising strain rate sensitivity, structural response in trauma, failure modes and residual function post-trauma.
The trauma of interest is blast and through developing good understanding of tissue response, novel and targeted protective measures can be developed.
This forms the other half of my research focused on materials such as sandwich composites for use in large-scale protective structures as well as personal protective equipment i. We develop and use various experimental techniques as well as numerical methods in our research, including: Full-scale explosives testing; Shock tubes and other gas gun facilities; Various conventional materials testing machines; Drop towers, Split Hopkinson Pressure Bars; High speed photography; Image Correlation; Structural integrity evaluation tools such as micro-ct, optical in-house serial sectioning tools for soft tissue, the Histocutter and acoustic measurements; Lung mechanics; and Numerical modelling of deformation, fluid-structure interaction and failure.
Part A, 42,journal articles, 3 book contributions, over 60 conference proceedings plus 5 more articles in or near submission.
However, the large number of animals per assay, complexity of protocols, and sensitivity to environmental perturbations render research on C.
During my post-doc at Georgia Tech, I have exploited the possibilities of microfluidics to enable traditionally challenging types of screens on first larval stage L1 and adult nematodes. The study of first larval stage C.
I overcame this challenge by developing a microfluidic platform that uses nanoliter droplets of a reversible hydrogel to offer advanced manipulation of individual animals. This work paves the way for high-throughput screening of L1 nematodes with high-resolution imaging and will facilitate the study of post-embryonic development. I have also developed a microfluidic platform for combinatorial drug screening of adult nematodes. Due to the exponential increase of combinations with the number of individual components, traditional technologies require a large amount of chemicals rendering the screens impractical.
Ahmed A Bahrani | University of Kentucky - badz.info
I solved this bottleneck by creating a droplet-on-demand platform that enables the preparation of precise mixtures of reagents while handling nanoliter volumes and the delivery of the stimuli to the animals in a robust way.
Such a platform offers the possibility of performing combinatorial screens of rare compounds and identify therapeutic strategies. In the future, I plan on building on my experience with C. In addition, I intend to expand this approach to zebrafish, which will lead to an increase in throughput of assays by several orders of magnitude and open new exciting possibilities Ph.
Lu, Hydrogel-droplet microfluidic platform for high-resolution imaging and sorting of early larval Caenorhabditis elegans, Lab on Chip 6, front cover; highlighted on the website of HFSP 2. Garcia, Microfluidic-based generation of size-controlled, biofunctionalized synthetic polymer microgels for cell encapsulation, Advanced Materials 19 ; A.
Lu, A perspective on optical developments in microfluidic platforms for Caenorhabditis elegans research, Biomicrofluidics 8 G. Haghiri-Gosnet, A multicolor microfluidic droplet dye laser with single mode emission, Applied Physics Letters, 98 G.
As a graduate student at the University of Iowa, I studied the response of metastatic tumor cells to fluid shear forces encountered during blood-borne circulation. This work revealed a fundamental link between oncogenic signaling and fluid shear stress survival, and led to a US Patent for our shear stress model. Having developed a keen interest in the mechanics of tumor biology, I joined the lab of Dr. Here, my project focuses on the physical landscape of the brain tumor microenvironment.
As the PI of an NIH-funded fellowship, my data has provided a mechanistic link between tumor cell-autologous ECM production, tissue stiffening, and mechanical signaling in the pathogenesis of high grade brain tumors glioblastoma. The scale of this project ranges from the molecular including bioluminescence imaging, fluorescence and atomic force microscopy to the cellular culture systems that model normal and diseased brain tissue mechanics to the organismal level, where we have developed novel glioblastoma mouse models in which mechanical signaling can be regulated.
Biomedical Engineering » Networking
Weaver and I are preparing to submit a manuscript on this work, and my collaborative contributions outside of this project will result in publications in the fields of fibrosis, cancer, and bioengineering. I am beginning to apply for academic positions, where I plan to continue studying the brain tumor microenvironment from a multi-disciplinary perspective. My graduate and postdoctoral training has prepared me to achieve this goal.
In addition to becoming proficient at many laboratory techniques, I have gained extensive experience in scientific writing and speaking and have built an incredible network of basic and clinical researchers in chemical and bioengineering, pathology, and oncology. Resistance to fluid shear stress is a conserved biophysical property of malignant cells. PLoS One ;7 The ARF tumor suppressor inhibits tumor cell colonization in a novel mouse model of pancreatic ductal adenocarcinoma metastasis.
Molecular Cancer Research ; Jul;9 7: Journal of Biological Chemistry ; Oct 29; Recognized in Faculty of24 Sep Mercurio A: Chemotherapeutic Agents Up-regulate the Cytomegalovirus Promoter: Cancer Research ; Nov 1;67 This work involves a element annular array with a element imaging probe to be implemented on a single plane for the treatment of prostate cancer.
Another CMUT probe has also been created which is undergoing development and optimization for the high intensity contact ultrasound of brain tissue under MRI guidance in vivo testing is under way. This work is taking place at Inserm Institut national de la sante et de la recherche medicale in Lyon, France.
PhD in biomedical engineering from Drexel University, Philadelphia, PA in BSc in Electrical and Computer Engineering from University of Colorado in Boulder, CO in My PhD work involved the design optimization, manufacturing, and testing of a custom-made wearable therapeutic ultrasound applicator for chronic wound healing and syringe-free, non-invasive drug delivery. This work involved the use of finite-element modeling, Matlab simulation, manufacturing and bench calibrating the probe before using it for both in vitro and in vivo testing.
Further research during my PhD involved the characterization of various ultrasound probes for collaborative work in other therapeutic ultrasound applications over 8 publications. During my time as a PhD student I taught an ultrasound lab and an electronics lab course and also taught half of a semester of undergraduate statistics course in Bochum, Germany.
I was also a teaching assistant for six different biomedical engineering courses. Finite element static displacement optimization of khz flexural transducers for fully portable ultrasound applicator. Ultrasonics, 53 2Samuels, J. A human study and in vitro experiments. International Society for Optics and Photonics.
Biomedical Engineering News
Christopher Bawiec, Peter A. McGowan, and Youhan Sunny. The goal of the program is to assist the development of professional leaders who are not only superb scientists, but who also will advance the profession through an international outlook. I use a unique interdisciplinary and broad combination of techniques derived from physics, engineering and cell and molecular biology, which range from single cell in vitro to full scale in vivo animal models, and include clinical and patient oriented observations.
During my PhD, I investigated the role of keratin, a cell type specific family of intermediate filaments cytoskeletal protein, in the regulation of simple epithelial cells mechanical activity, notably by using an optical tweezers tool developed during my master. My postdoctoral research focuses on cell adaptation to matrix stiffness, both in terms of signaling and gene expression.
Most notably, I recently showed that matrix stiffness regulate alternative splicing, a fundamental process the give rise to protein diversity in cells. My research is complemented by tools and approaches to recreate and finely tune the cell ECM microenvironments in vitro and in vivo.
The long term aim of my research is to understand how the interplay between cell mechanotransduction, ECM mechanics and cues from the microenvironment regulates alternative splicing. In line with my research aims, I have an interest in the regulation of mechanotransduction at the signaling level, principally through the involvement of cell type specific expression of intermediate filaments and their associated proteins, which remain widely understudied despite their.
My future research will continue to bridge clinical and basic sciences at an interdisciplinary level to understand the connection between tissue mechanics and the cellular changes that drive disease progression and normal physiological processes. Bordeleau F, Mason B. However, due to the lack of appropriate tools, little is known about how cellular perception of time-varying signals can regulate or misregulate cellular behavior.
In my graduate and postdoctoral work, I pioneered light-sensitive optogenetic proteins and methodologies to uniquely address this question: My early work applying these tools suggests that cells are exquisitely sensitive to temporal regulation: I aim to lead a multidisciplinary research group to broadly understand how cells process and perceive dynamic signals across biological contexts, how this perception is altered in disease, and how we can exploit this understanding for biomedical applications.
I earned my Ph. I engineered this protein to regulate b-catenin signaling among other targets -- Bugaj et al, Nature Communications,and I used this to probe adult neural stem cell differentiation as a function of b-catenin dynamics. Unexpectedly, we discovered a quality control program within stem cells that responds to inappropriate timing of morphogenic signals.
I further found that this filtering can be altered in a series of BRAF mutant cell cancers, and that this filter rewiring can cause cells to misperceive signaling inputs and proliferate in response to non-proliferative signals Bugaj et al, submitted to Cell.
To do this, I also engineered custom incubator-compatible, high throughput illumination hardware allowing optogenetic experiments in or well plates patent pending. These results serve as a strong proof of principle that optogenetics can reveal how cells filter and respond to dynamic signals and how this process can importantly change in cancer.
Optogenetic protein clustering and signaling activation in mammalian cells. Bringing next generation therapeutics to the clinic through synthetic biology. We will certainly miss Sahba in the Schmidt Lab! Congrats to Deanna on passing qualifying exam!
- News & Events
She did a fantastic job presenting on her proposed research to create cardiac tissue mimics for understanding congenital heart defects and for potentially treating cardiac disease. Deanna pictured with her committee members, Drs. Mojica Santiago to the lab! Jorge joins our lab on August 15, Jorge will be working on 3D printing and patterning of hydrogels for neural regeneration applications. Welcome to the team Jorge! Farewell and good luck to Jonathan!
Jon has had inspiration to take a slightly different career path and to instead pursue opportunities in the area of science writing. He is excited to start a science communications internship in Washington DC. We wish him well on his exciting new endeavors! Congrats to our team on a great publication!! The Anselmo lab focuses on designing cell therapies, specifically microbiomes in the gastrointestinal tract. By studying the imbalance of microbes and microbiota bacteria in the body, which can cause disease and cancer, the lab is designing delivery platforms that can be used to regulate the microbiota composition.
Additionally, the lab focuses on developing drug delivery systems using nanoparticles for vascular disease and cancer. Tran Ngo- Johns Hopkins University: She will be working in Dr.
The Hur Research Group focuses on developing microfluidic platforms that utilize the principles of fluid dynamics to understand relationships between cellular functions and their physical phenotype. This summer, Tran will help to synthesize liposomes using extrusion method to generate vesicles with biotin labeled lipids and coated with micro-beads. These liposomes will be used as model for exosome separation in microfluidics channels.
The goal is to use developed microfluidic channels to separate exosomes which contain rich nucleic acid content, floating in virtually all bodily fluids, to understand the inter-cellular signals that may propose a great potential for non-invasive molecular diagnostics.
MEET THE FACULTY CANDIDATES
Monica Wall — Worcester Polytechnic Institute: She will be conducting research with Dr. Glen Gaudette, who works in the field of myocardial regeneration. In addition to research, participants will receive training in mentoring, become a mentor to a middle-school student, and participate in creating an outreach program for middle-school students.
They will lead a one-week research experience known as the WPI Innovations in Bioengineering program. Congrats to Mustafa on MS! While in the lab, Mustafa did exciting research on electrical stimulation of nerve cells in collaboration with postdoc, Dr. Good luck to Mustafa on his next adventures! This conference focused on extracellular matrix-based scaffolds and decellularized scaffolds. Great fit for our research!
This is a great way to hear about all the wonderful research being conducted by our talented UG students. At this event, we present our graduating UG s with a special certificate of appreciation — this year, we acknowledged Nicole Bohmann.
Nicole worked under the mentorship of postdoc, Dr. After all the great presentations, we celebrated with a special catered lunch! Congrats to all of our amazing students for wonderful talks!
Nik Agrawal, Ben Spearman and Jonathan Griffin showcased how biomaterials can be modified for potential spinal cord injury therapies as well as for peripheral nerve applications. Below are picture Nik and Jonathan during the poster session. Kaitlyn is a Materials Science and Engineering undergraduate student who has been working in the Schmidt Lab since Fall under the direct mentorship of postdoctoral associate Dr.
Kaitlyn is optimizing vitrification-mediated decellularization, wherein vitrification is ice-free cryopreservation of organs and tissues to prevent ice crystal formation that damages tissue architecture. For her proposal for the University Scholars award, Kaitlyn will be working on creating hydrogels for in vitro modeling of healthy and pathological lungs.
These hydrogels then would be encapsulated with lung-specific cells to recapitulate healthy and diseased lung microenvironments. This project is especially exciting because it aims to develop new and gentle methods to create engineered lung scaffolds for transplantation and in vitro modeling. She received the full travel scholarship as well as an award for one of the best poster presentations in physical chemistry, which was the discipline of her poster.
AxoSim is trying to create Nerve-on-a-Chip platforms, mainly for high throughput, high content pharmaceutical applications. Hieu joins AxoSim after completing his postdoc with Dr.
John Troy at Northwestern University. The award recipients will be honored in a reception on November 14, at 5: The International Student Awards acknowledge the outstanding achievements of our international students. The awards recognizes outstanding contributions of international students to promote and foster continued involvement and outstanding achievement. This year, students were not just selected for outstanding academic achievements, but also for demonstrated contributions outside of the classroom.
Click here for a list of all recipients. Nik was received this prestigious award because he is an exceptionally talented student and a valuable member of the Schmidt Lab and the BME Department.
Nik is intelligent, disciplined, has good analytical skills, and is committed to self-improvement. In addition, Nik is more than a researcher — he contributes immensely to the department, the university and to the community. Materials Chemistry B, 4: Such successes include his recent appointment as Chair of the Student Laboratory Safety Council for our department.
As part of the safety council he works on identifying potential lab safety issues in the department and providing potential solutions to the problems. The council also releases monthly newsletters containing safety tips, identifying potential hazardous chemicals and trivia questions for increasing participation from fellow graduate and undergraduate students and faculty members.
Nik has always shown interest in promoting safe laboratory practices and is currently working on being a certified safety engineer. In addition Nik is an active member of the Graduate Student Council for the Biomedical Engineering Department and has served as Secretory — and Vice President — in the past. Congrats to Michaela for passing qualifying exam! July 14, Congratulations to Michaela for doing a fantastic job on her research proposal part of her qualifying exam, to fully be advanced to PhD candidacy.
Pictured below is Michaela, 2nd from left, with her committee members, Drs. Way to go Michaela!! After receiving his Ph. His new research group will focus on understanding and exploiting nanometer scale structures and dynamical processes within the context of biophysical and biomedical research. His proposed project is described below. The purpose of this proposal is to develop a framework for studying renal vascular disease by accurately reconstructing the renal microvascular niche in a microphysiological system that allows for the systematic study of the factors that contribute to vascular dysfunction.
We anticipate that new findings will lead to the identification of novel therapies to renal vascular disease. Considered the greatest distinction of any student award given by the Herbert Wertheim College of Engineering at UF, the Gator Engineering Attribute Awards are intended to provide an ideal guide for all members of the UF Engineering community. They honor five undergraduate and five Ph. Congratulations Ella on this significant recognition! Ella has worked in our lab most recently on injectable nucleus pulposus with Dr.
Becky Wachs who was a postdoc in the Schmidt Lab and who is now a faculty member at U. For the competition, NSF received over 13, applications, and made 2, award offers. Many of our undergraduate students contributed as well, in addition to Stacy her first publication from our lab too! These articles should appear in print soon. Links to abstracts are provided below: Lee, Y-J Huang, A. Journal of Materials Chemistry B. Becky has been with the lab since June and has been a huge asset to the group, helping to write six successful proposals!
We celebrated with a traditional Schmidt Lab party at Dr. Several of our collaborators who have worked with Becky also joined the party, including Dr. Chelsea Simmons, and Dr. Becky will be missed by us all, but we wish her well in the next stage of her career and life!
This proposal seeks to investigate the underlying mechanisms of cardiovascular malformation resulting in cardiac defects. We will create benchtop hydrogel mimics to study the impact of genetic and environmental factors on development of cardiovascular malformations.